Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy of H1 receptor antagonist plus pregabalin capsules in skin pruritus: A controlled study

Lingxi Li¹, Jing Chen² , Jiao Chu³

¹Department of Dermatology, The Second Hospital of Shandong University, Shandong Province, 260000, China; ²Department of Pharmacy, Qingdao Hiser Hospital Affiliated to Qingdao University, Shandong Province, 260000, China; ³Department of Spinal Surgery, Qingdao Central Hospital, Shandong Province, 260000, China.

For correspondence:- Jing Chen Email: miconggua472135131@163.com

Accepted: 5 November 2021 Published: 31 December 2021

Citation: Li L, Chen J, Chu J. Efficacy of H1 receptor antagonist plus pregabalin capsules in skin pruritus: A controlled study. Trop J Pharm Res 2021; 20(12):2633-2638 doi: 10.4314/tjpr.v20i12.25

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the effectiveness of histamine H1 receptor antagonist combined with pregabalin capsules in the treatment of skin pruritus.

Methods: From June 2018 to June 2019, 90 patients who presented pruritus in the Second Hospital of Shandong University were recruited and randomized into control and study groups. The control group was treated topically with conventional drug (umiconazole ointment), while the study group was treated with the combination of histamine and H1 receptor antagonist and pregabalin capsules. Clinical efficacy for the two groups was assessed.

Results: The study group obtained clinical efficiency than the control group (p < 0.05); No significant difference was found in the degree of pruritus between the two groups before treatment and 12 h after treatment (p > 0.05). At 48 and 72 h after treatment, the two groups showed significant differences in the degree of pruritus (p < 0.05). The study group had a significantly lower Pittsburgh Sleep Quality Index (PSQI) score after treatment when compared to the control group (p < 0.001). A lower incidence of adverse reactions was observed in the study group in contrast to the control group (p < 0.05). The level of parathyroid hormone (PTH) of the study group was significantly lower than that of the control group (p < 0.001).

Conclusion: The combined use of Histamine H1 receptor antagonist with pregabalin capsule effectively alleviates the degree of pruritus, ensures good sleep quality, and lowers the incidence of adverse reactions.

Keywords: Histamine H1 receptor antagonist, Pregabalin capsule, Skin pruritus, Parathyroid hormone, Sleep quality